[Meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinylbis(methane)-S]platinum(II) chloride new water soluble platinum complexes with high anti-breast cancer activities

Gust, Ronald ; Heinrich, Heike ; Krauser, Rudolf ; Schönenberger, Helmut

---

Alternative links to fulltext:

---

Details

Item type:	Article
Journal or Publication Title:	Inorganica chimica acta
Publisher:	Elsevier
Volume:	285
Number of Issue or Book Chapter:	2
Page Range:	pp. 184-189
Date:	1999
Additional Information (public):	CAN 130:261019 78-7 Inorganic Chemicals and Reactions 221619-05-2; 221619-08-5 Role: FMU (Formation, unclassified), FORM (Formation, nonpreparative) (formation from chloride analog); 221619-01-8P Role: SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (prepn. as breast tumor inhibitors); 221648-13-1P Role: RCT (Reactant), SPN (Synthetic preparation), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses), RACT (Reactant or reagent) (prepn. as breast tumor inhibitors and substitution with iodide); 67-68-5 (DMSO); 118097-81-7; 118141-52-9 Role: RCT (Reactant), RACT (Reactant or reagent) (reactant for prepn. of platinum bis(fluorophenyl)ethylenediamine DMSO complexes)
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Alumni or Retired Professors > Prof. Schönenberger Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:	Value Type 1999:141478 Other
Keywords:	Antitumor agents (mammary gland platinum bis(fluorophenyl)ethylenediamine DMSO complexes as) Mammary gland (neoplasm, inhibitors platinum bis(fluorophenyl)ethylenediamine DMSO complexes as) platinum fluorophenylethylenediamine DMSO prepn breast antitumor agent
Dewey Decimal Classification:	500 Science > 540 Chemistry & allied sciences
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	17719

Export bibliographical data

ASCII CitationAtomBibTeXData Cite XMLDataCite XML OAIDublin CoreDublin Core (LZV)EndNoteHTML CitationJSONJSON LDMETSMODSOPENAIREOpenAPCRDF+N-TriplesRDF+N3RDF+XMLReferReference ManagerSimple MetadataXMLopenCostxMetaDissPlus

---

Abstract

The synthesis, the physicochem. and the breast cancer inhibiting properties of [meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinylbis(methane)-S]platinum(II) chlorides (meso- and rac-4F-PtCl(DMSO)) are described. Rac-4F-PtCl(DMSO) surpasses the std. carboplatin in its effect on the human MCF-7 breast cancer cell line and is more resistant than its dichloroplatinum(II) analog ...

Abstract

The synthesis, the physicochem. and the breast cancer inhibiting properties of [meso- and rac-1,2-bis(4-fluorophenyl)ethylenediamine]chloro[sulfinylbis(methane)-S]platinum(II) chlorides (meso- and rac-4F-PtCl(DMSO)) are described. Rac-4F-PtCl(DMSO) surpasses the std. carboplatin in its effect on the human MCF-7 breast cancer cell line and is more resistant than its dichloroplatinum(II) analog rac-4F-PtCl2 against attack of nucleophiles, a prerequisite for sufficient stability in physiol. environments and consequently for marked antitumor activity in vivo.

---

---

Metadata last modified: 24 May 2018 12:18

Owner only: item control page

Altmetric

Altmetric

Altmetric

Alternative Statistics (altmetrics)

More literature (via CORE)

More literature (via CORE)

More literature (via CORE)

More literature (via CORE)