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Molecular analysis of the interaction of the four histamine receptor subtypes with antidepressant and antipsychotic drugs

Appl, Heidrun (2010) Molecular analysis of the interaction of the four histamine receptor subtypes with antidepressant and antipsychotic drugs. PhD, Universität Regensburg.

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Date of publication of this fulltext: 26 Nov 2010 15:36

Abstract (English)

Antidepressant and antipsychotic drugs are known to affect multiple molecular targets. Beside their determinant effects on the neurotransmission of serotonin, norepinephrine and dopamine via several transporters and receptors, they may also modulate muscarinic acetylcholine receptors and the histamine H1 receptor (H1R). Consequently, these drugs do not only yield unique profiles of desired ...


Translation of the abstract (German)

Antidepressiva und Neuroleptika entfalten ihre spezifischen Wirkungen durch Interaktionen mit zahlreichen Zielstrukturen. Neben den Wirkungen auf die serotonerge, noradrenerge und dopaminerge Neurotransmission durch verschiedene Transporter und Rezeptoren interagieren sie ebenso mit muskarinischen Acetylcholin-Rezeptoren und dem Histamin H1 Rezeptor (H1R). Infolgedessen zeichnen sich diese ...


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Item type:Thesis of the University of Regensburg (PhD)
Date:26 November 2010
Referee:Prof. Dr. Roland Seifert and Prof. Dr. Dr. Ekkehard Haen
Date of exam:29 October 2010
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Interdisciplinary Subject Network:Not selected
Keywords:Histamin, G-Protein gekoppelter Rezeptor, Radioaktivität, Molekulare Pharmakologie, Psychopharmaka, Antidepressiva, Neuroleptika, Plasmakonzentration, therapeutischer Referenzbereich; histamine, G protein-coupled receptor, radioactivity, molecular pharmacology, psychiatric medication, antidepressants, antipsychotics, plasma concentration, therapeutic reference range
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
600 Technology > 610 Medical sciences Medicine
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17824
Owner only: item control page


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