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DNA sequence encoded repression of rRNA gene transcription in chromatin

Felle, Max, Exler, Josef H., Merkl, Rainer, Dachauer, Karoline, Brehm, Alexander, Grummt, Ingrid and Längst, Gernot (2010) DNA sequence encoded repression of rRNA gene transcription in chromatin. Nucleic acids research 38 (16), pp. 5304-5314.

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Abstract

Eukaryotic genomes are packaged into nucleosomes that occlude DNA from interacting with most DNA-binding proteins. Nucleosome positioning and chromatin organization is critical for gene regulation. We have investigated the mechanism by which nucleosomes are positioned at the promoters of active and silent rRNA genes (rDNA). The reconstitution of nucleosomes on rDNA results in sequence-dependent ...

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Item type:Article
Date:25 April 2010
Institutions:Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Rainer Merkl
Identification Number:
ValueType
20421213PubMed ID
10.1093/nar/gkq263DOI
Classification:
NotationType
Chromatin Assembly and Disassembly/drug effectsMESH
DNA, Ribosomal/chemistryMESH
Gene Expression RegulationMESH
Gene SilencingMESH
Genes, rRNAMESH
Kanamycin/pharmacologyMESH
Nucleosomes/metabolismMESH
Promoter Regions, GeneticMESH
RNA Polymerase I/metabolismMESH
Transcription, Genetic/drug effectsMESH
Transcriptional ActivationMESH
Dewey Decimal Classification:500 Science > 570 Life sciences
000 Computer science, information & general works > 004 Computer science
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:17987
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