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Red-fluorescent argininamide-type NPY Y(1) receptor antagonists as pharmacological tools

Keller, Max ; Erdmann, Daniela ; Teng, Shangjun ; Pop, Nathalie ; Pluym, Nikola ; Bernhardt, Günther ; Buschauer, Armin


Fluorescently labelled NPY Y1 receptor (Y1R) ligands were synthesized by connecting pyrylium and cyanine dyes with the argininamide-type Y1R antagonist core structure by linkers, covering a wide variety in length and chemical nature, attached to the guanidine group. The most promising fluorescent probes had Y1R affinities (radioligand binding) and antagonistic activities (calcium assay) in the ...


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