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Red-fluorescent argininamide-type NPY Y(1) receptor antagonists as pharmacological tools

Keller, Max, Erdmann, Daniela, Teng, Shangjun, Pop, Nathalie, Pluym, Nikola, Bernhardt, Günther and Buschauer, Armin (2011) Red-fluorescent argininamide-type NPY Y(1) receptor antagonists as pharmacological tools. Bioorganic & Medicinal Chemistry 19 (9), pp. 2859-2878.

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Fluorescently labelled NPY Y1 receptor (Y1R) ligands were synthesized by connecting pyrylium and cyanine dyes with the argininamide-type Y1R antagonist core structure by linkers, covering a wide variety in length and chemical nature, attached to the guanidine group. The most promising fluorescent probes had Y1R affinities (radioligand binding) and antagonistic activities (calcium assay) in the ...


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Item type:Article
Date:16 March 2011
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Projects:GRK 760, Graduiertenkolleg Medizinische Chemie
Identification Number:
21493077PubMed ID
Related URLs:
http://www.sciencedirect.com/science/MiamiMultiMediaURL/B6TF8-52FVDD4-4/B6TF8-52FVDD4-4-1/5220/html/S0968089611002264/f82d36d5aa7b84bc4647c190c530e20f/mmc1.pdfSupplementary Material
Keywords:NPY Y1 receptor; fluorescent ligands; Y1R binding; Y1R antagonism; argininamide derivatives; confocal microscopy; flow cytometry
Dewey Decimal Classification:500 Science > 570 Life sciences
500 Science > 540 Chemistry & allied sciences
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:18611
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