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Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools

Erdmann, Daniela (2011) Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools. PhD, Universität Regensburg.

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Date of publication of this fulltext: 17 Jan 2011 14:35

Abstract (English)

Histamine receptors, as typical aminergic G-protein coupled receptors (GPCRs), are subject of an extensive research project in our laboratory, aiming at receptor subtype (H1R, H2R, H3R, H4R) selective agonists and antagonists. The H2-receptor (H2R) plays a key role in gastric acid secretion, and H2R antagonists revolutionized the treatment of peptic ulcer/gastric acid related diseases. ...

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Translation of the abstract (German)

Histamin-Rezeptoren, typische aminerge G-Protein-gekoppelte Rezeptoren, sind Gegenstand eines umfangreichen Forschungsprojekts unserer Arbeitsgruppe, das auf Rezeptorsubtyp selektive (H1R, H2R, H3R, H4R) Agonisten und Antagonisten abzielt. Der H2-Rezeptor (H2R) spielt eine Schlüsselrolle in der Regulation der Magensäuresekretion; die Entwicklung von H2R-Antagonisten revolutionierte seinerzeit die ...

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Item type:Thesis of the University of Regensburg (PhD)
Date:17 January 2011
Referee:Prof. Dr. Armin Buschauer and Prof. Dr. Günther Bernhardt
Date of exam:16 December 2010
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Interdisciplinary Subject Network:Not selected
Keywords:Durchflusszytometrie, Fluoreszenzligand, Radioligand, G-Protein gekoppelter Rezeptor, Histaminrezeptor, Quadratsäureamid, GPCR, Histamine, pharmacological tools, Piperidinomethylalkylamine, flow cytometry, fluorescent ligand, H2-receptor, H3-receptor, structure-activity relationship, squaramide
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:19062
Owner only: item control page

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