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Histamine H2- and H3-receptor antagonists: Synthesis and characterization of radiolabelled and fluorescent pharmacological tools

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Erdmann, Daniela
Date of publication of this fulltext: 17 Jan 2011 14:35

Abstract (English)

Histamine receptors, as typical aminergic G-protein coupled receptors (GPCRs), are subject of an extensive research project in our laboratory, aiming at receptor subtype (H1R, H2R, H3R, H4R) selective agonists and antagonists. The H2-receptor (H2R) plays a key role in gastric acid secretion, and H2R antagonists revolutionized the treatment of peptic ulcer/gastric acid related diseases. ...


Translation of the abstract (German)

Histamin-Rezeptoren, typische aminerge G-Protein-gekoppelte Rezeptoren, sind Gegenstand eines umfangreichen Forschungsprojekts unserer Arbeitsgruppe, das auf Rezeptorsubtyp selektive (H1R, H2R, H3R, H4R) Agonisten und Antagonisten abzielt. Der H2-Rezeptor (H2R) spielt eine Schlüsselrolle in der Regulation der Magensäuresekretion; die Entwicklung von H2R-Antagonisten revolutionierte seinerzeit die ...


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