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Paradoxical stimulatory effects of the “standard” histamine H4-receptor antagonist JNJ7777120: The H4-receptor joins the club of 7TM receptors exhibiting functional selectivity

Seifert, Roland ; Schneider, Erich H. ; Dove, Stefan ; Brunskole, Irena ; Neumann, Detlef ; Strasser, Andrea ; Buschauer, Armin



Abstract

The histamine H4-receptor (H4R) is expressed in several cell types of the immune system and is assumed to play an important pro-inflammatory role in various diseases including bronchial asthma, atopic dermatitis and pruritus. Accordingly, H4R antagonists have been suggested to provide valuable drugs for the treatment of the afore-mentioned diseases. Over the past decade, the indole derivative, ...

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