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Paradoxical stimulatory effects of the “standard” histamine H4-receptor antagonist JNJ7777120: The H4-receptor joins the club of 7TM receptors exhibiting functional selectivity

Seifert, Roland ; Schneider, Erich H. ; Dove, Stefan ; Brunskole, Irena ; Neumann, Detlef ; Strasser, Andrea ; Buschauer, Armin



Abstract

The histamine H-4 receptor (H4R) is expressed in several cell types of the immune system and is assumed to play an important pro-inflammatory role in various diseases, including bronchial asthma, atopic dermatitis, and pruritus. Accordingly, H4R antagonists have been suggested to provide valuable drugs for the treatment of these diseases. Over the past decade, the indole derivative ...

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