Photodegradation of some quinolones used as antimicrobial therapeutics

URN to cite this document:: urn:nbn:de:bvb:355-epub-196329
DOI to cite this document:: 10.5283/epub.19632

Tiefenbacher, E. M. ; Haen, Ekkehard ; Przybilla, B. ; Kurz, H.

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Date of publication of this fulltext: 17 Feb 2011 07:39

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Abstract

The photostability of the fluoroquinolones ciprofloxacin (CPX), ofloxacin (OFX), and fleroxacin (FLX) toward ultraviolet irradiation (UVA) and room light was investigated in dilute aqueous solutions. A series of photoproducts was observed by high-performance liquid chromatography (HPLC) for all three drugs. As little as 1 h of exposure to room light was enough for the formation of detectable ...