Über die Bedeutung der Applikationsgeschwindigkeit für die pharmakokinetischen Parameter von Azlocillin und Mezlocillin (=The effect of infusion rate on pharmacokinetic parameters of azlocillin and mezlocillin)

URN zum Zitieren dieses Dokuments:

urn:nbn:de:bvb:355-epub-196489 Copy

DOI zum Zitieren dieses Dokuments:

10.5283/epub.19648 Copy

Haen, Ekkehard ; Remien, J. ; Richter, E. ; Frank, U. ; Adam, D.

Vorschau

PDF (890kB)

Veröffentlichungsdatum dieses Volltextes: 17 Mrz 2011 08:02

---

Alternative Links zum Volltext:Pubmed

---

---

Details

Dokumentenart:	Artikel
Open Access Art:	Rechteübertragung -1994
Titel eines Journals oder einer Zeitschrift:	Arzneimittel-Forschung = Drug research
Verlag:	Editio-Cantor-Verl.
Band:	35
Nummer des Zeitschriftenheftes oder des Kapitels:	5
Seitenbereich:	S. 864-868
Datum:	1985
Institutionen:	Medizin > Lehrstuhl für Psychiatrie und Psychotherapie
Identifikationsnummer:	Wert Typ 4026911 PubMed-ID
Klassifikation:	Notation Art Adult MESH Azlocillin/urine MESH Chromatography, High Pressure Liquid MESH Half-Life MESH Humans MESH Infusions, Parenteral MESH Kinetics MESH Male MESH Mezlocillin/urine MESH
Dewey-Dezimal-Klassifikation:	600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
Status:	Veröffentlicht
Begutachtet:	Unbekannt / Keine Angabe
An der Universität Regensburg entstanden:	Unbekannt / Keine Angabe
Dokumenten-ID:	19648

Vorschau

Bibliographische Daten exportieren

ASCII CitationAtomBibTeXData Cite XMLDataCite XML OAIDublin CoreDublin Core (LZV)EndNoteHTML CitationJSONJSON LDMETSMODSOPENAIREOpenAPCRDF+N-TriplesRDF+N3RDF+XMLReferReference ManagerSimple MetadataXMLopenCostxMetaDissPlus

---

Zusammenfassung

Azlocillin (Securopen) and mezlocillin (Baypen) were given to 3 healthy subjects as intravenous infusion. The dose of 4 g was administered to each person within 5, 15, and 30 min in a randomized crossover design. Using HPLC the unchanged penicillin antibiotics were determined quantitatively, their metabolites were assessed qualitatively. The same specimens were also studied by means of a bioassay ...

Zusammenfassung

Azlocillin (Securopen) and mezlocillin (Baypen) were given to 3 healthy subjects as intravenous infusion. The dose of 4 g was administered to each person within 5, 15, and 30 min in a randomized crossover design. Using HPLC the unchanged penicillin antibiotics were determined quantitatively, their metabolites were assessed qualitatively. The same specimens were also studied by means of a bioassay (agar diffusion technique). Both methods yielded similar serum and urine concentrations besides the urinary excretion of azlocillin. Here the bioassay measured higher amounts indicating an antibacterially active metabolite being excreted in the urine. No dependence upon infusion time was found. Since both drugs were tested with the same dosis in the same subjects, their pharmacokinetic parameters could be compared: mezlocillin, being more lipophilic than azlocillin, showed a higher volume of distribution and therefore lower serum concentrations. Renal clearance was the same for both drugs, but mezlocillin was excreted to a smaller extent in the urine. Higher total clearance and shorter elimination half-life of mezlocillin indicate a greater extrarenal elimination. The results suggest fast application of both penicillins. There is no pharmacokinetic reason for a prolongation of infusion times.

---

---

Metadaten zuletzt geändert: 26 Nov 2020 07:30

Nur für Besitzer und Autoren: Kontrollseite des Eintrags

Downloadstatistik

Downloadstatistik

Downloadstatistik

Downloadstatistik

Downloads

Downloads im Monat während des letzten Jahres

Altmetric

Altmetric

Altmetric

Alternative Statistik (altmetrics)

Weitere Literatur (mittels CORE)

Weitere Literatur (mittels CORE)

Weitere Literatur (mittels CORE)

Weitere Literatur (mittels CORE)