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Prostaglandin I2 release following mesenteric traction during abdominal surgery is mediated by cyclooxygenase-1

Bucher, Michael ; Kees, Frieder K. ; Messmann, Barbara ; Lunz, Dirk ; Rath, Stephan ; Zelenka, Marek ; Schlitt, Hans J. ; Hobbhahn, Jonny
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Date of publication of this fulltext: 05 Aug 2009 13:35


Abstract

Our study aimed to determine the role of cyclooxygenase-2 in the release of prostaglandin-(PG)-I2 following mesenteric traction during abdominal surgery. In a prospective double-blind, randomized, placebo-controlled study, 40 patients electively scheduled for non-laparoscopic abdominal surgery, were pretreated with the cyclooxygenase-2 inhibitor parecoxib (n=20) or placebo (n=20). Heart rate, ...

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