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Bradykinin shifts endothelial fluid passage from para- to transcellular routes

Riethmüller, C. ; Wegener, Joachim ; Oberleithner, H.



Abstract

The signalling peptide bradykinin (BK) is implicated in inflammation and angiogenesis. It promotes fluid transport from blood vessels to interstitial space, and thus facilitates oedema formation. To clarify whether paracellular or transcellular pathways mediate this effect, we investigated the BK-stimulated fluid transport across endothelial monolayers in vitro by comparison of electrical and ...

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