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Junctional adhesion molecule A participates in the formation of apico-basal polarity through different domains

Rehder, D. ; Iden, S. ; Nasdala, I. ; Wegener, Joachim ; Meyer zu Brickwedde, M.K. ; Vestweber, D. ; Ebnet, K.



Abstract

Junctional adhesion molecule (JAM)-A is an integral membrane protein at tight junctions of epithelial cells which associates with the cell polarity protein PAR-3. Here, we demonstrate that downregulation of JAM-A impairs the ability of MDCK II cells to form cysts in a threedimensional matrix indicating the requirement of JAM-A for the development of apico-basal polarity. To define the regions of ...

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