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The impact of glia-derived ECM on the barrier function of cerebral endothelial cells: an in vitro study.

Zozulya, A. ; Hartmann, C. ; Wegener, Joachim ; Galla, H. J.


The blood-brain barrier (BBB) is composed of the cerebral microvascular endothelium, which, together with astrocytes, pericytes, and the extracellular matrix (ECM), contributes to a "neurovascular unit". It was our objective to clarify the impact of endogenous extracellular matrices on the barrier function of BBB microvascular endothelial cells cultured in vitro. The study was performed in two ...


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