This cumulative dissertation presents four articles focussing on diagnosis, treatment and pathophysiology of the restless legs syndrome:
1) Fulda S, Beitinger ME, Reppermund S, Winkelmann J, Wetter TC. Short-term attention and verbal fluency is decreased in restless legs syndrome patients. Movement Disorders 2010; 25: 2641-2648. DOI 10.1002/mds.23353
2) Fulda S, Wetter TC. Where dopamine meets opioids: a meta-analysis of the placebo effect in restless legs syndrome treatment studies. Brain 2008; 131: 902-917. DOI 10.1093/brain/awm244
3) Fulda S, Stalla GK, Wetter TC. Prevalence of the restless legs syndrome in transsexual patients: the hormonal hypothesis revisited. Journal of Neurology 2007; 254: 1748-1749. DOI 10.1007/100415-007-0624-6
4) Winkelmann J, Schormaier B, Lichtner P, Ripke S, Xiong L, Jalilzadeh S, Fulda S, Pütz B, Eckstein G, Hauk S, Trenkwalder C, Zimprich A, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Peglau I, Eisensehr I, Montplaisir J, Turecki G, Rouleau G, Gieger C, Illig T, Wichmann HE, Holsboer F, Müller-Myhsok B, Meitinger T. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nat Genet 2007; 39(8): 1000-1006. DOI 10.1038/ng2099

In dieser kumulativen Dissertation werden vier Arbeiten aus dem Bereich der Diagnose, Behandlung und Pathophysiologie des Restless Legs Syndrom dargestellt:
1) Fulda S, Beitinger ME, Reppermund S, Winkelmann J, Wetter TC. Short-term attention and verbal fluency is decreased in restless legs syndrome patients. Movement Disorders 2010; 25: 2641-2648. DOI 10.1002/mds.23353
2) Fulda S, Wetter TC. Where dopamine meets opioids: a meta-analysis of the placebo effect in restless legs syndrome treatment studies. Brain 2008; 131: 902-917. DOI 10.1093/brain/awm244
3) Fulda S, Stalla GK, Wetter TC. Prevalence of the restless legs syndrome in transsexual patients: the hormonal hypothesis revisited. Journal of Neurology 2007; 254: 1748-1749. DOI 10.1007/100415-007-0624-6
4) Winkelmann J, Schormaier B, Lichtner P, Ripke S, Xiong L, Jalilzadeh S, Fulda S, Pütz B, Eckstein G, Hauk S, Trenkwalder C, Zimprich A, Stiasny-Kolster K, Oertel W, Bachmann CG, Paulus W, Peglau I, Eisensehr I, Montplaisir J, Turecki G, Rouleau G, Gieger C, Illig T, Wichmann HE, Holsboer F, Müller-Myhsok B, Meitinger T. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nat Genet 2007; 39(8): 1000-1006. DOI 10.1038/ng2099