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Functional reconstitution of human neuropeptide Y (NPY) Y2 and Y4 receptors in Sf9 insect cells

Pop, Nathalie ; Igel, Patrick ; Brennauer, Albert ; Cabrele, Chiara ; Bernhardt, Günther ; Seifert, Roland ; Buschauer, Armin


The four functionally expressed human neuropeptide Y receptor subtypes (hY1R, hY2R, hY4R, hY5R) belong to class A of the G-protein-coupled receptors (GPCRs) and interact with pertussis toxin-sensitive Gi/o proteins. The number of small molecules described as ligands for hY1R and hY5R exceeds by far those for hY2R. Potent non-peptidergic ligands for the hY4R are not available so far. Here, we ...


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