Pluym, Nikola, Brennauer, Albert, Keller, Max, Ziemek, Ralf, Pop, Nathalie, Bernhardt, Günther and Buschauer, Armin (2011) Application of the guanidine – acylguanidine bioisosteric approach to argininamide-type NPY Y2 receptor antagonists. ChemMedChem 6 (9), pp. 1727-1738.
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Abstract
Strongly basic groups such as guanidine moieties are crucial structural elements but compromising drug-likeness of numerous biologically active compounds including ligands of G-protein coupled receptors (GPCRs). As part of a project focusing on the search for guanidine bioisosteres, argininamide-type neuropeptide Y (NPY) Y2 receptor (Y2R) antagonists related to BIIE0246 were synthesized. Starting ...
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| Item type: | Article | ||||||
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| Date: | 20 June 2011 | ||||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer) | ||||||
| Projects: | GRK 760, Graduiertenkolleg Medizinische Chemie | ||||||
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| Keywords: | neuropeptide Y; NPY; Y2 receptor; bioisosterism; acylguanidine; argininamide | ||||||
| Dewey Decimal Classification: | 500 Science > 570 Life sciences 500 Science > 540 Chemistry & allied sciences | ||||||
| Status: | Published | ||||||
| Refereed: | Yes, this version has been refereed | ||||||
| Created at the University of Regensburg: | Yes | ||||||
| Item ID: | 20420 |
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