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Role of the second and third extracellular loops of the histamine H4 receptor in receptor activation

Brunskole, Irena ; Strasser, Andrea ; Seifert, Roland ; Buschauer, Armin


The histamine H4 receptor subtype (H4R) belongs to the class 1 of G protein-coupled receptors and is involved in inflammatory and immunological processes. The aim of this study was to elucidate the importance of extracellular regions for the large species differences between human (h) and canine (c) H4R. Therefore, chimeric receptors were generated by replacing corresponding domains of the hH4R ...


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