Go to content
UR Home

Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening

Seitz, Tobias ; Thoma, Ralf ; Schoch, Guillaume A. ; Stihle, Martine ; Benz, Jörg ; D'Arcy, Brigitte ; Wiget, Andrea ; Ruf, Armin ; Hennig, Michael ; Sterner, Reinhard



Abstract

The human glucocorticoid receptor ligand-binding domain (hGR-LBD) is an important drug target for the treatment of various diseases. However, the low intrinsic stability and solubility of hGR-LBD have rendered its purification and biophysical characterization difficult. In order to overcome these problems, we have stabilized hGR-LBD by a combination of random mutagenesis and high-throughput ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons