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Analysis of intermediates of the methionine and polyamine metabolism by liquid chromatography-tandem mass spectrometry

URN to cite this document:
urn:nbn:de:bvb:355-epub-213956
Stevens, Axel Peter
Date of publication of this fulltext: 05 Aug 2011 08:52


Abstract (English)

5’-Deoxy-5’-methylthioadenosine (MTA) is formed in the course of the synthesis of polyamines from S-adenosylmethionine (SAM). Tumors lack the enzyme methylthioadenosine phosphorylase (MTAP), which metabolizes MTA, and should accumulate MTA. In a first step, a method for quantification of MTA by liquid chromatography-mass spectrometry was developed and the postulated accumulation of MTA in tumors ...

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Translation of the abstract (German)

5’-Deoxy-5’-methylthioadenosin (MTA) entsteht im Zuge der Polyaminsynthese aus S-Adenosylmethionin (SAM). Das für den Abbau von MTA nötige Enzym Methylthioadenosinphosphorylase (MTAP) ist in vielen Tumoren nicht vorhanden oder zumindest in seiner Aktivität stark vermindert und somit wird postuliert, dass in Tumoren MTA akkumuliert. Zuerst wurde eine Methode zur quantitativen Bestimmung von MTA ...

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