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Nucleosomes protect DNA from DNA methylation in vivo and in vitro

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Felle, Max ; Hoffmeister, Helen ; Rothammer, Julia ; Fuchs, Andreas ; Exler, Josef H. ; Längst, Gernot
License: Creative Commons Attribution Non-commercial 3.0
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Date of publication of this fulltext: 26 Jul 2011 08:03


Positioned nucleosomes limit the access of proteins to DNA. However, the impact of nucleosomes on DNA methylation in vitro and in vivo is poorly understood. Here, we performed a detailed analysis of nucleosome binding and nucleosomal DNA methylation by the de novo methyltransferases. We show that compared to linker DNA, nucleosomal DNA is largely devoid of CpG methylation. ATP-dependent chromatin ...


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