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Design of benzimidazole- and benzoxazole-2-thione derivatives as inhibitors of bacterial hyaluronan lyase

Braun, Stephan ; Botzki, Alexander ; Salmen, Sunnhild ; Textor, Christian ; Bernhardt, Günther ; Dove, Stefan ; Buschauer, Armin


Bacterial hyaluronan lyases (Hyal) degrade hyaluronan, an important component of the extracellular matrix, and are involved in microbial spread. Hyal inhibitors may serve as tools to study the role of the enzyme, its substrates and products in the course of bacterial infections. Moreover, such enzyme inhibitors are potential candidates for antibacterial combination therapy. Based on crystal ...


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