Evidence for a less high acceptor substrate specificity of gastric histamine methyltransferase: methylation of imidazole compounds

URN to cite this document:: urn:nbn:de:bvb:355-epub-218991
DOI to cite this document:: 10.5283/epub.21899

Barth, H. ; Crombach, M. ; Schunack, W. ; Lorenz, Wilfried

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Date of publication of this fulltext: 25 Aug 2011 07:34

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Abstract

The transmethylation catalysed by HMT (EC 2.1.1.8)* has been considered as absolutely specific for histamine as acceptor substrate. In this investigation Nα-MH, Nα,NαDMH, spinaceamine and synthetically prepared 4-[(2-amino-ethylmercapto)-methyl]-imidazole could be identified as further methyl-group accepting substrates (optimum substrate concentration ~ 1 mM), but the yield of extractable ...