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Molecular and cellular analysis of aminergic G protein-coupled receptors: histamine H2, H4 and β2-adrenergic receptors, a scientific paradigm

URN to cite this document:
urn:nbn:de:bvb:355-epub-229639
Brunskole, Irena
Date of publication of this fulltext: 15 Dec 2011 08:04


Abstract (English)

About one third of the drugs currently available on the market address cell membrane-integrated G protein-coupled receptors (GPCRs). As such, the histamine H2 receptor (H2R) and the β2-adrenergic receptor (β2AR) have been successfully targeted in the treatment of frequently occurring gastric disorders and asthma, respectively. The novel histaminergic GPCR, the histamine H4 receptor (H4R), is ...

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Translation of the abstract (German)

Ein Drittel der derzeit auf dem Markt befindlichen Arzneimittel bindet an G Protein-gekoppelte Rezeptoren (GPCR). Drei Vertreter dieser GPCR-Familie standen im Mittelpunkt dieser Arbeit: der Histamin H2 Rezeptor (H2R), der β2-adrenerge Rezeptor (β2AR) und der Histamin H4 Rezeptor (H4R). Die H2R Antagonisten werden zur Therapie von peptischen Ulcera eingesetzt, die β2AR Agonisten in der Behandlung ...

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