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Modeling molecular signaling and gene expression using Dynamic Nested Effects Models

URN to cite this document:
urn:nbn:de:bvb:355-epub-229962
Anchang, Benedict Nchang
Date of publication of this fulltext: 20 Dec 2011 09:53


Abstract (English)

Cellular decision making in differentiation, proliferation or apoptosis is mediated by molecular signaling processes, which control the regulation and expression of genes. Vice versa, the expression of genes can trigger the activity of signaling pathways. I summarize methodology by Markowetz et al. known as the Nested Effects Models (NEMs) to reconstruct static non-transcriptional networks using ...

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Translation of the abstract (German)

Die zelluläre Entscheidungsfindung in der Differenzierung, der Zellproliferation oder der Apoptose wird durch molekulare Signalprozesse, die die Genregulation und -expression steuern, vermittelt. Andersherum kann die Genexpression die Aktivität der Signalverläufe auslösen. Ich fasse die Methodik von Markowetz et al., bekannt als Nested Effects Models (NEMs), zusammen um statische ...

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