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In silico analysis of the histaprodifen induced pathway of the guinea-pig histamine H1 receptor

Strasser, Andrea ; Wittmann, Hans-Joachim



Abstract

The binding of (partial) agonists in the binding pocket of biogenic amine receptors induces a conformational change from the inactive to the active state of the receptors. There is only little knowledge about the binding pathways of ligands into binding pocket on molecular level. So far, it was not possible with molecular dynamic simulations to observe the ligand binding and receptor activation. ...

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