Lipopeptides are effective stimulators of tyrosine phosphorylation in human myeloid cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-232211

Offermanns, S. ; Seifert, Roland ; Metzger, J. W. ; Jung, G. ; Lieberknecht, A. ; Schmidt, U. ; Schultz, Günter

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Date of publication of this fulltext: 24 Jan 2012 08:04

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Abstract

Synthetic lipopeptide analogues of the N-terminus of bacterial lipoprotein are effective activators of macrophages, neutrophils and lymphocytes. We studied the effect of the lipopeptide N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]- (R)-cysteinyl-(S)-seryl-(S)-lysyl-(S)-lysyl-(S)-lysyl-(S)-lysine [Pam3Cys-Ser-(Lys)4] on tyrosine phosphorylation in dibutyryl-cyclic-AMP-differentiated HL-60 ...