Zusammenfassung
Tethering drug substances to it gel network is all effective way of controlling the release kinetics of hydrogel-based drug delivery systems Here, we report oil in situ forming, biodegradable hydrogels that allow for the covalent attachment of peptides or proteins. Hydrogels were prepared by step-growth polymerization of branched poly(ethylene glycol). The gel strength ranged from 1075 to 2435 ...
Zusammenfassung
Tethering drug substances to it gel network is all effective way of controlling the release kinetics of hydrogel-based drug delivery systems Here, we report oil in situ forming, biodegradable hydrogels that allow for the covalent attachment of peptides or proteins. Hydrogels were prepared by step-growth polymerization of branched poly(ethylene glycol). The gel strength ranged from 1075 to 2435 Pit: the degradation time varied between 24 and 120 h. Fluorescence recovery after photobleaching showed that fluorescently labeled bovine serum albumin (FITC-BSA) was Successfully bound to the gel network during gel formation Within 168 h, the mobility of the tethered molecules gradually increased due to polymer degradation Using FITC-BSA and lysozyme as model proteins, we showed the potential of the developed hydrogels for time-controlled release. The obtained release profiles had a sigmoidal shape and matched the degradation profile very well. protein release wits complete after 96 h
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