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Hydrogel-based drug delivery systems: Comparison of drug diffusivity and release kinetics

Brandl, Ferdinand ; Kastner, Fritz ; Gschwind, R. M. ; Blunk, Torsten ; Teßmar, Jörg ; Göpferich, Achim


Hydrogels are extensively studied as matrices for the controlled release of macromolecules. To evaluate the mobility of embedded molecules, these drug delivery systems are usually characterized by release studies. However, these experiments are time-consuming and their reliability is often poor. In this study, gels were prepared by step-growth polymerization of poly(ethylene glycol) (PEG) and ...


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