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Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides

URN to cite this document:
urn:nbn:de:bvb:355-epub-232448
Seifert, Roland ; Schultz, Günter ; Richter-Freund, M. ; Metzger, J. ; Wiesmüller, K. H. ; Jung, G. ; Bessler, W. G. ; Hauschildt, S.
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Date of publication of this fulltext: 24 Jan 2012 13:38


Abstract

Upon exposure to the bacterial chemotactic peptide fMet-Leu-Phe, human neutrophils release lysozyme and generate superoxide anions (O2.-). The synthetic lipoamino acid N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteine (Pam3Cys), which is derived from the N-terminus of bacterial lipoprotein, when attached to Ser-(Lys)4 [giving Pam3Cys-Ser-(Lys)4], activated O2.- formation and ...

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