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Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides

Seifert, Roland, Schultz, Günter, Richter-Freund, M., Metzger, J., Wiesmüller, K. H., Jung, G., Bessler, W. G. and Hauschildt, S. (1990) Activation of superoxide formation and lysozyme release in human neutrophils by the synthetic lipopeptide Pam3Cys-Ser-(Lys)4. Involvement of guanine-nucleotide-binding proteins and synergism with chemotactic peptides. The Biochemical journal 267 (3), pp. 795-802.

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Abstract

Upon exposure to the bacterial chemotactic peptide fMet-Leu-Phe, human neutrophils release lysozyme and generate superoxide anions (O2.-). The synthetic lipoamino acid N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteine (Pam3Cys), which is derived from the N-terminus of bacterial lipoprotein, when attached to Ser-(Lys)4 [giving Pam3Cys-Ser-(Lys)4], activated O2.- formation and ...

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Item type:Article
Date:1990
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:
ValueType
2160237PubMed ID
Classification:
NotationType
Dose-Response Relationship, DrugMESH
Drug SynergismMESH
Exocytosis/drug effectsMESH
GTP-Binding Proteins/physiologyMESH
HumansMESH
Lipoproteins/pharmacologyMESH
Muramidase/secretionMESH
N-Formylmethionine Leucyl-Phenylalanine/pharmacologyMESH
Neutrophils/metabolismMESH
Oligopeptides/pharmacologyMESH
Platelet Activating Factor/pharmacologyMESH
Structure-Activity RelationshipMESH
Superoxides/metabolismMESH
Tumor Necrosis Factor-alpha/pharmacologyMESH
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:23244
Owner only: item control page

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