Lack of effect of opioid peptides, morphine and naloxone on superoxide formation in human neutrophils and HL-60 leukemic cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-232569
DOI to cite this document:: 10.5283/epub.23256

Seifert, Roland ; Burde, R. ; Schultz, Günter

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Date of publication of this fulltext: 24 Jan 2012 13:25

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Abstract

There are controversial reports in the literature concerning the effects of opioids on superoxide (O2-) formation in phagocytes, these agents being either inhibitory or stimulatory. We re-examined this issue and compared the effects of the chemotactic peptide, N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe), phorbol myristate acetate (PMA), ATP, platelet activating factor (PAF), ...