Formation and release of nitric oxide from human neutrophils and HL-60 cells induced by a chemotactic peptide, platelet activating factor and leukotriene B4

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urn:nbn:de:bvb:355-epub-232590 Copy

Schmidt, H. H. ; Seifert, Roland ; Böhme, E.

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Date of publication of this fulltext: 24 Jan 2012 13:34

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Details

Item type:	Article
Journal or Publication Title:	FEBS letters
Publisher:	Elsevier
Volume:	244
Number of Issue or Book Chapter:	2
Page Range:	pp. 357-360
Date:	1989
Institutions:	Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert)
Identification Number:	Value Type 2537760 PubMed ID
Classification:	Notation Type Bucladesine/pharmacology MESH Calcitriol/pharmacology MESH Canavanine/pharmacology MESH Cell Line MESH Humans MESH Kinetics MESH Leukemia, Promyelocytic, Acute MESH Leukotriene B4/pharmacology MESH Luminescence MESH N-Formylmethionine Leucyl-Phenylalanine/pharmacology MESH Neutrophils/metabolism MESH Nitric Oxide/metabolism MESH Platelet Activating Factor/pharmacology MESH
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine 600 Technology > 615 Pharmacy
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	23259

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Abstract

Vascular endothelial cells and neutrophils synthesize and release potent vasodilatatory factors, i.e. endothelium-derived relaxing factors (EDRF) and neutrophil-derived relaxing factors (NDRF). One EDRF has been identified as nitric oxide (NO) derived from arginine. We studied the synthesis and release of NO from human neutrophils stimulated with the chemotactic peptide ...

Abstract

Vascular endothelial cells and neutrophils synthesize and release potent vasodilatatory factors, i.e. endothelium-derived relaxing factors (EDRF) and neutrophil-derived relaxing factors (NDRF). One EDRF has been identified as nitric oxide (NO) derived from arginine. We studied the synthesis and release of NO from human neutrophils stimulated with the chemotactic peptide N-formyl-L-methionyl-L-leucyl-L-phenylalanine, platelet activating factor or leukotriene B4. The formation and release of NO was enhanced several-fold in the presence of superoxide dismutase, probably by inhibiting superoxide-induced breakdown of NO. The formation and release of NO but not the formation of superoxide anions was decreased in neutrophils pretreated with L-canavanine, an inhibitor of arginine-utilizing enzymes. Our data suggest that at least one NDRF is identical with NO or another labile NO containing compound derived from arginine.

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