Activation of protein kinase C by cis- and trans-fatty acids and its potentiation by diacylglycerol

URN to cite this document:: urn:nbn:de:bvb:355-epub-232666
DOI to cite this document:: 10.5283/epub.23266

Seifert, Roland ; Schächtele, C. ; Rosenthal, W. ; Schultz, Günter

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Date of publication of this fulltext: 24 Jan 2012 13:07

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Abstract

Both cis- and trans-unsaturated but not saturated fatty acids activated protein kinase C purified to apparent homogeneity from rat brain. Fatty-acid-induced enzyme activation was not more than additive with that by phospholipids and was potentiated by diacylglycerol. Recently, we demonstrated that cis- and trans-unsaturated fatty acids induced platelet aggregation and phosphorylation of specific ...