Stimulus-dependent inhibition of platelet aggregation by the protein kinase C inhibitors polymyxin B, H-7 and staurosporine

URN to cite this document:: urn:nbn:de:bvb:355-epub-232699
DOI to cite this document:: 10.5283/epub.23269

Schächtele, C. ; Seifert, Roland ; Osswald, H.

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Date of publication of this fulltext: 26 Jan 2012 08:32

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Abstract

Thrombin, 1-oleoyl-2-acetyl-rac-glycerol (OAG), cis- or trans-octadecadienoic acids (linoleic and linolelaidic acid) and the synergistic combination of octadecadienoic acids plus OAG lead to the activation of gel-filtered human platelets, i.e. aggregation via protein kinase C (PKC). Platelet activation by thrombin was only slightly suppressed by polymyxin B, ...