Guanine nucleotides stimulate NADPH oxidase in membranes of human neutrophils

URN to cite this document:: urn:nbn:de:bvb:355-epub-232822
DOI to cite this document:: 10.5283/epub.23282

Seifert, Roland ; Rosenthal, W. ; Schultz, Günter

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Date of publication of this fulltext: 26 Jan 2012 08:30

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Abstract

In the chain of events by which chemotactic peptides stimulate NADPH oxidase-catalyzed superoxide formation in human neutrophils, the involvements of a pertussis toxin-sensitive guanine nucleotide-binding protein (N-protein), mobilization of intracellular calcium and protein kinase C stimulation have been proposed. Superoxide formation was studied in membranes from human neutrophils; NADPH ...