Partial inhibition of human neutrophil activation by FK-506 at supratherapeutic concentrations

URN to cite this document:: urn:nbn:de:bvb:355-epub-232887
DOI to cite this document:: 10.5283/epub.23288

Wenzel-Seifert, Katharina ; Seifert, Roland

Preview

PDF
(827kB)

Date of publication of this fulltext: 25 Jan 2012 10:40

Alternative links to fulltext:Pubmed

Details

Preview

Export bibliographical data

Abstract

The macrolide, FK-506, is a potent and effective inhibitor of lymphocyte activation. We studied the effects of FK-506 on human neutrophil activation induced by chemoattractants and by various substances which circumvent receptor stimulation. After preincubation for 5 min at 37 degrees C, FK-506 (1 microM) inhibited N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMet-Leu-Phe)- or ...