Preparations of Rp-cyclic adenosine 3',5'-phosphorothioate (Rp-cAMPS) can contain biologically active amounts of adenosine

URN to cite this document:: urn:nbn:de:bvb:355-epub-232902
DOI to cite this document:: 10.5283/epub.23290

Musgrave, I. F. ; Genieser, H. G. ; Maronde, E. ; Seifert, Roland

Preview

PDF
(431kB)

Date of publication of this fulltext: 25 Jan 2012 13:58

Alternative links to fulltext:Pubmed

Details

Preview

Export bibliographical data

Abstract

Superoxide anion (O2-.) production from human neutrophils stimulated by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP, 1 microM) was inhibited by preparations of the inhibitor of cAMP-dependent protein kinase, Rp-cyclic adenosine 3',5'-phosphorothioate (Rp-cAMPS, 100 microM). This effect of Rp-cAMPS was reversed by xanthine amine congener (0.1 microM), an adenosine receptor antagonist, and ...