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Preparations of Rp-cyclic adenosine 3',5'-phosphorothioate (Rp-cAMPS) can contain biologically active amounts of adenosine

URN to cite this document:
urn:nbn:de:bvb:355-epub-232902
Musgrave, I. F. ; Genieser, H. G. ; Maronde, E. ; Seifert, Roland
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Date of publication of this fulltext: 25 Jan 2012 13:58


Abstract

Superoxide anion (O2-.) production from human neutrophils stimulated by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP, 1 microM) was inhibited by preparations of the inhibitor of cAMP-dependent protein kinase, Rp-cyclic adenosine 3',5'-phosphorothioate (Rp-cAMPS, 100 microM). This effect of Rp-cAMPS was reversed by xanthine amine congener (0.1 microM), an adenosine receptor antagonist, and ...

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