Maitotoxin activates cation channels distinct from the receptor-activated non-selective cation channels of HL-60 cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-232971
DOI to cite this document:: 10.5283/epub.23297

Musgrave, I. F. ; Seifert, Roland ; Schultz, Günter

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Date of publication of this fulltext: 26 Jan 2012 08:24

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Abstract

We investigated whether maitotoxin activates non-selective cation channels, as was recently proposed [Soergel, Yasumoto, Daly and Gusovsky (1992) Mol. Pharmacol. 41, 487-493]. Stimulation of dibutyryl cyclic AMP-differentiated HL-60 cells with the chemotactic peptide N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; 0.1 microM), the Ca(2+)-ATPase inhibitor thapsigargin (0.1 microM) or ...