Synthetic lipopeptide Pam3CysSer(Lys)4 is an effective activator of human platelets

URN to cite this document:: urn:nbn:de:bvb:355-epub-232986
DOI to cite this document:: 10.5283/epub.23298

Berger, M. ; Offermanns, S. ; Seifert, Roland ; Schultz, Günter

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Date of publication of this fulltext: 26 Jan 2012 08:22

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Abstract

Lipopeptide analogues of the NH2-terminus of bacterial lipoprotein are known to induce activation of macrophages, neutrophils, and lymphocytes. We studied the effect of the lipopeptide N-palmitoyl-S-[2,3-bis(palmitoyloxy)-(2RS)-propyl]-(R)-cysteinyl-( S)-seryl-(S)-lysyl-(S)-lysyl-(S)-lysyl-(S)-lysine [Pam3CysSer(Lys)4] on several functions of human platelets. Pam3CysSer(Lys)4 led to the ...