Structural and Mutational Analysis of Substrate Complexation by Anthranilate Phosphoribosyltransferase from Sulfolobus solfataricus

DOI zum Zitieren dieses Dokuments:: 10.5283/epub.233

Marino, Marco ; Deuss, Miriam ; Svergun, Dmitri I. ; Konarev, Petr V. ; Sterner, Reinhard ; Mayans, Olga

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Veröffentlichungsdatum dieses Volltextes: 05 Aug 2009 13:22

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Zusammenfassung

The metabolic synthesis and degradation of essential nucleotide compounds are primarily carried out by phosphoribosyltransferases (PRT) and nucleoside phosphorylases (NP), respectively. Despite the resemblance of their reactions, five classes of PRTs and NPs exist, where anthranilate PRT (AnPRT) constitutes the only evolutionary link between synthesis and degradation processes. We have ...