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Some taste substances are direct activators of G-proteins

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Naim, M. ; Seifert, Roland ; Nürnberg, B. ; Grünbaum, L. ; Schultz, Günter
Date of publication of this fulltext: 26 Jan 2012 08:17


Amphiphilic substances may stimulate cellular events through direct activation of G-proteins. The present experiments indicate that several amphiphilic sweeteners and the bitter tastant, quinine, activate transducin and Gi/Go-proteins. Concentrations of taste substances required to activate G-proteins in vitro correlated with those used to elicit taste. These data support the hypothesis that amphiphilic taste substances may elicit taste through direct activation of G-proteins.

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