Human neutrophils and HL-60 cells do not possess alpha 2-adrenoceptors

URN to cite this document:: urn:nbn:de:bvb:355-epub-233048
DOI to cite this document:: 10.5283/epub.23304

Musgrave, I. F. ; Seifert, Roland

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Date of publication of this fulltext: 26 Jan 2012 07:30

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Abstract

Human neutrophils have been reported to possess both alpha 2- and beta 2-adrenoceptors. While activation of beta 2-adrenoceptors is known to inhibit N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP)-induced superoxide anion (O2-) production, the functional role of alpha 2-adrenoceptors is not known. We studied the effects of a range of structurally unrelated alpha 2-adrenoceptor agonists on ...