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L-dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction

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Lange, Klaus W. ; Robbins, T. W. ; Marsden, C. D. ; James, M. ; Owen, A. M. ; Paul, G. M.
Date of publication of this fulltext: 20 Jul 2012 11:10


A group of ten patients with idiopathic Parkinson's disease (PD) was tested on a series of automated tests of learning, memory, planning and attention whilst either on or off L-dopa medication. Controlled withdrawal of L-dopa interfered with aspects of performance on three of the tests that had previously been shown to be sensitive to frontal lobe dysfunction; a spatial working memory task, the ...


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