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L-dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction

Lange, Klaus W., Robbins, T. W., Marsden, C. D., James, M., Owen, A. M. and Paul, G. M. (1992) L-dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction. Psychopharmacology 107 (2-3), pp. 394-404.

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Abstract

A group of ten patients with idiopathic Parkinson's disease (PD) was tested on a series of automated tests of learning, memory, planning and attention whilst either on or off L-dopa medication. Controlled withdrawal of L-dopa interfered with aspects of performance on three of the tests that had previously been shown to be sensitive to frontal lobe dysfunction; a spatial working memory task, the ...

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Item type:Article
Date:1992
Institutions:Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange
Identification Number:
ValueType
1615139PubMed ID
Classification:
NotationType
Brain Diseases/physiopathologyMESH
Cognition Disorders/psychologyMESH
Discrimination (Psychology)/drug effectsMESH
FemaleMESH
Frontal Lobe/physiopathologyMESH
HumansMESH
Learning/drug effectsMESH
Levodopa/therapeutic useMESH
MaleMESH
Memory/drug effectsMESH
Middle AgedMESH
Parkinson Disease/drug therapyMESH
Psychomotor Performance/drug effectsMESH
Substance Withdrawal Syndrome/physiopathologyMESH
Dewey Decimal Classification:100 Philosophy & psychology > 150 Psychology
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:25434
Owner only: item control page

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