L-dopa withdrawal in Parkinson's disease selectively impairs cognitive performance in tests sensitive to frontal lobe dysfunction

URN to cite this document:: urn:nbn:de:bvb:355-epub-254346
DOI to cite this document:: 10.5283/epub.25434

Lange, Klaus W. ; Robbins, T. W. ; Marsden, C. D. ; James, M. ; Owen, A. M. ; Paul, G. M.

Preview

PDF
(1MB)

Date of publication of this fulltext: 20 Jul 2012 11:10

Alternative links to fulltext:Pubmed

Details

Preview

Export bibliographical data

Abstract

A group of ten patients with idiopathic Parkinson's disease (PD) was tested on a series of automated tests of learning, memory, planning and attention whilst either on or off L-dopa medication. Controlled withdrawal of L-dopa interfered with aspects of performance on three of the tests that had previously been shown to be sensitive to frontal lobe dysfunction; a spatial working memory task, the ...