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Synergism of the AMPA-antagonist NBQX and the NMDA-antagonist CPP with L-dopa in models of Parkinson's disease

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Löschmann, P. A. ; Lange, Klaus W. ; Kunow, M. ; Rettig, K. J. ; Jähnig, P. ; Honoré, T. ; Turski, L. ; Wachtel, H. ; Jenner, P. ; Marsden, C. D.
Date of publication of this fulltext: 20 Jul 2012 09:49


Degeneration of dopaminergic nigrostriatal neurons in Parkinson's disease results in an overactivity of excitatory glutamatergic projections from the subthalamic nucleus to the output nuclei of the basal ganglia resulting in rigidity and akinesia. In theory pharmacological blockade of these overactive systems should improve parkinsonian symptomatology. The selective AMPA-antagonist NBQX and the ...


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