Motor activity following the administration of selective D-1 and D-2 dopaminergic drugs to normal common marmosets

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Löschmann, P. A. ; Smith, L. A. ; Lange, Klaus W. ; Jaehnig, P. ; Jenner, P. ; Marsden, C. D.

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Date of publication of this fulltext: 20 Jul 2012 10:03

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Details

Item type:	Article
Date:	1991
Institutions:	Human Sciences > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange
Identification Number:	Value Type 1686813 PubMed ID
Classification:	Notation Type 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology MESH Animals MESH Apomorphine/pharmacology MESH Benzazepines/pharmacology MESH Callithrix MESH Dopamine Agents/pharmacology MESH Dopamine Antagonists MESH Dose-Response Relationship, Drug MESH Drug Interactions MESH Ergolines/pharmacology MESH Female MESH Male MESH Motor Activity/drug effects MESH Quinpirole MESH Raclopride MESH Receptors, Dopamine/drug effects MESH Receptors, Dopamine D1 MESH Receptors, Dopamine D2 MESH Salicylamides/pharmacology MESH Stereotyped Behavior/drug effects MESH
Dewey Decimal Classification:	100 Philosophy & psychology > 150 Psychology
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Unknown
Item ID:	25441

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Abstract

In normal common marmosets administration of the D-1/D-2 agonist apomorphine or the selective D-2 agonist quinpirole caused a dose-dependent increase in motor activity and induced stereotyped behaviour. Both the selective D-2 antagonist raclopride and the selective D-1 antagonist SCH 23390 inhibited normal locomotor activity and induced catalepsy. Quinpirole- and apomorphine-induced motor ...

Abstract

In normal common marmosets administration of the D-1/D-2 agonist apomorphine or the selective D-2 agonist quinpirole caused a dose-dependent increase in motor activity and induced stereotyped behaviour. Both the selective D-2 antagonist raclopride and the selective D-1 antagonist SCH 23390 inhibited normal locomotor activity and induced catalepsy. Quinpirole- and apomorphine-induced motor activity were potently inhibited by pretreatment with raclopride. The effects of quinpirole, but not apomorphine, were weakly inhibited by SCH 23390. The selective D-1 partial agonist SKF 38393 decreased motor activity and did not induce grooming, oral movements or other behaviours. SKF 38393 inhibited motor activity induced by the administration of quinpirole but did not alter apomorphine-induced motor behaviour. Locomotor activity in normal common marmosets appears to be mediated mainly via D-2 systems. In contrast to rodents, administration of SKF 38393 does not induce behavioural activation and there does not appear to be a facilitating effect of D-1 systems on D-2 function in the normal common marmoset. However, the ability of both SKF 38393 and SCH 23390 to inhibit quinpirole locomotor activity suggests some interaction between D-1 and D-2 systems to occur in this species.

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Metadata last modified: 02 Jun 2018 21:54

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