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ATP-binding cassette transporters in immortalised human brain microvascular endothelial cells in normal and hypoxic conditions

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Lindner, Christian ; Sigrüner, Alexander ; Walther, Franziska ; Bogdahn, Ulrich ; Couraud, Pierre O. ; Schmitz, Gerd ; Schlachetzki, Felix
License: Creative Commons: Attribution 3.0
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Date of publication of this fulltext: 07 Sep 2012 06:48


Background Rapid reperfusion following ischemia is the most effective therapy in stroke therapy. However, the success may be compromised by ischemia & reperfusion (I/R) injury and at the human blood-brain barrier (BBB), therefore the effects on transendothelial transport are of special interest. Current studies suggest the ATP-binding cassette (ABC) transporters to be regulated upon ischemic ...


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