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Resequencing of the auxiliary GABAB receptor subunit gene KCTD12 in chronic tinnitus

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Sand, Philipp G. ; Langguth, Berthold ; Itzhacki, Jacob ; Bauer, Angelika ; Geis, Sandra ; Cárdenas-Conejo, E. ; Pimentel, Vanessa ; Kleinjung, Tobias ; Zuge, Elisabeth
License: Creative Commons: Attribution-Noncommercial 3.0
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Date of publication of this fulltext: 07 Sep 2012 06:35


Tinnitus is a common and often incapacitating hearing disorder marked by the perception of phantom sounds. Susceptibility factors remain largely unknown but GABAB receptor signaling has long been implicated in the response to treatment and, putatively, in the etiology of the disorder. We hypothesized that variation in KCTD12, the gene encoding an auxiliary subunit of GABAB receptors, could help ...


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