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Conservation of the folding mechanism between a thermostable (βα)8-barrel enzyme, its evolutionary relatives, and ancestral precursors generated by protein design

URN to cite this document:
urn:nbn:de:bvb:355-epub-265559
Carstensen, Linn
Date of publication of this fulltext: 05 Nov 2012 07:25


Abstract (English)

The (βα)8-barrel is amongst the most ancient, frequent and versatile enzyme folds. Sequence and structure comparisons suggest that modern (βα)8-barrels have divergently evolved from a common ancestor, which raises the question whether they share the same folding mechanism. Here, this problem was appraoched by using the thermostable cyclase subunit HisF of imidazole glycerol phosphate (ImGP) ...

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Translation of the abstract (German)

Das (βα)8-barrel gehört zu den ursprünglichsten, vielseitigsten und häufigsten Faltungstypen bekannter Proteine. Sequenz- und Strukturvergleiche legen nahe, dass (βα)8-barrel Enzyme das Produkt einer divergenten Evolution ausgehend von einem gemeinsamen Vorläufer sind. Daraus ergibt sich die Frage, ob alle Vertreter einen gemeinsamen Faltungsmechanismus aufweisen. Die thermostabile ...

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