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Novel azulene derivatives for the treatment of erectile dysfunction

Löber, Stefan, Hübner, Harald, Buschauer, Armin, Sanna, Fabrizio, Argiolas, Antonio, Melis, Maria Rosaria and Gmeiner, Peter (2012) Novel azulene derivatives for the treatment of erectile dysfunction. Bioorganic & medicinal chemistry letters 22 (23), pp. 7151-7154.

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Based on the dopamine D(4) receptor partial agonist FAUC 3019, a series of azulenylmethylpiperazines was synthesized and affinities for the monoaminergic GPCRs including dopamine, serotonin, histamine and α-adrenergic receptor subtypes were determined. Ligand efficacies of the most promising test compounds revealed the N,N-dimethylaminomethyl substituted azulene 11 to be the most potent D(4) ...


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Item type:Article
Date:6 October 2012
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry II (Prof. Buschauer)
Identification Number:
23099096PubMed ID
Related URLs:
http://www.sciencedirect.com/science/article/pii/S0960894X1201219X#MMCvFirstSupplementary Material
Keywords:Penile erection; Erectile dysfunction; Azulene; Dopamine D4; Partial agonists
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
500 Science > 570 Life sciences
600 Technology > 615 Pharmacy
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Partially
Item ID:26576
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