Molecular Analysis of the Interaction of Bordetella pertussis Adenylyl Cyclase with Fluorescent Nucleotides

URN to cite this document:: urn:nbn:de:bvb:355-epub-26631
DOI to cite this document:: 10.5283/epub.2663

Göttle, Martin ; Dove, Stefan ; Steindel, Phillip ; Shen, Yuequan ; Tang, Wei-Jen

; Geduhn, Jens ; König, Burkhard

; Seifert, Roland

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Date of publication of this fulltext: 05 Aug 2009 13:40

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Abstract

The calmodulin ( CaM)- dependent adenylyl cyclase ( AC) toxin from Bordetella pertussis ( CyaA) substantially contributes to the pathogenesis of whooping cough. Thus, potent and selective CyaA inhibitors may be valuable drugs for prophylaxis of this disease. We examined the interactions of fluorescent 2 ', 3 '- Nmethylanthraniloyl ( MANT)-, anthraniloyl- and trinitrophenyl ( TNP)- substituted ...