Molecular Analysis of the Interaction of Bordetella pertussis Adenylyl Cyclase with Fluorescent Nucleotides

URN to cite this document:: urn:nbn:de:bvb:355-epub-26631
DOI to cite this document:: 10.5283/epub.2663

Göttle, Martin ; Dove, Stefan ; Steindel, Phillip ; Shen, Yuequan ; Tang, Wei-Jen ; Geduhn, Jens ; König, Burkhard ; Seifert, Roland

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Date of publication of this fulltext: 05 Aug 2009 13:40

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Abstract

The calmodulin (CaM)-dependent adenylyl cyclase (AC) toxin from Bordetella pertussis (CyaA) substantially contributes to the pathogenesis of whooping cough. Thus, potent and selective CyaA inhibitors may be valuable drugs for prophylaxis of this disease. We examined the interactions of fluorescent 2',3'-N-methylanthraniloyl (MANT)-, anthraniloyl- and trinitrophenyl (TNP)-substituted nucleotides ...