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Generation of a homology model of the human histamine H₃ receptor for ligand docking and pharmacophore-based screening

Schlegel, Birgit, Laggner, Christian, Meier, Rene, Langer, Thierry, Schnell, David, Seifert, Roland, Stark, Holger, Höltje, Hans-Dieter and Sippl, Wolfgang (2007) Generation of a homology model of the human histamine H₃ receptor for ligand docking and pharmacophore-based screening. Journal of Computer-Aided Molecular Design.

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Abstract

The human histamine H₃ receptor (hH₃R) is a G-protein coupled receptor (GPCR), which modulates the release of various neurotransmitters in the central and peripheral nervous system and therefore is a potential target in the therapy of numerous diseases. Although ligands addressing this receptor are already known, the discovery of alternative lead structures represents an important goal in drug ...

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Item type:Article
Date:2007
Institutions:Chemistry and Pharmacy > Institute of Pharmacy
Identification Number:
ValueType
10.1007/s10822-007-9127-xDOI
Keywords:Histamine; H₃ receptor; Docking; Molecular dynamics; GOLD; Catalyst; Pharmacophore; Rhodopsin
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Unknown
Item ID:2664
Owner only: item control page

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