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Generation of a homology model of the human histamine H₃ receptor for ligand docking and pharmacophore-based screening

URN to cite this document:
urn:nbn:de:bvb:355-epub-26644
Schlegel, Birgit ; Laggner, Christian ; Meier, Rene ; Langer, Thierry ; Schnell, David ; Seifert, Roland ; Stark, Holger ; Höltje, Hans-Dieter ; Sippl, Wolfgang
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Date of publication of this fulltext: 05 Aug 2009 13:40


Abstract

The human histamine H₃ receptor (hH₃R) is a G-protein coupled receptor (GPCR), which modulates the release of various neurotransmitters in the central and peripheral nervous system and therefore is a potential target in the therapy of numerous diseases. Although ligands addressing this receptor are already known, the discovery of alternative lead structures represents an important goal in drug ...

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