Go to content
UR Home

Functional Adenylyl Cyclase Inhibition in Murine
Cardiomyocytes by 2'(3')-O-(N-Methylanthraniloyl)-Guanosine
5'-[γ-Thio]triphosphate

URN to cite this document:
urn:nbn:de:bvb:355-epub-26684
Rottlaender, Dennis ; Matthes, Jan ; Vatner, Stephen F. ; Seifert, Roland ; Herzig, Stefan
[img]
Preview
PDF
(497kB)
Date of publication of this fulltext: 05 Aug 2009 13:40


Abstract

beta(1)-Adrenergic receptor activation stimulates cardiac L-type Ca2+ channels via adenylyl cyclases (ACs), with AC5 and AC6 being the most important cardiac isoforms. Recently, we have identified 2'(3')- O-(N-methylanthraniloyl)-guanosine 5'-[gamma-thio] triphosphate (MANT-GTP gamma S) as a potent competitive AC inhibitor. Intriguingly, MANT-GTP gamma S inhibits AC5 and -6 more potently than ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons