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Functional Adenylyl Cyclase Inhibition in Murine
Cardiomyocytes by 2'(3')-O-(N-Methylanthraniloyl)-Guanosine
5'-[γ-Thio]triphosphate

URN to cite this document:
urn:nbn:de:bvb:355-epub-26684
Rottlaender, Dennis ; Matthes, Jan ; Vatner, Stephen F. ; Seifert, Roland ; Herzig, Stefan
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Date of publication of this fulltext: 05 Aug 2009 13:40


Abstract

β₁-Adrenergic receptor activation stimulates cardiac L-type Ca²⁺ channels via adenylyl cyclases (ACs), with AC5 and AC6 being the most important cardiac isoforms. Recently, we have identified 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-[γ-thio-]triphosphate (MANT-GTPγS) as a potent competitive AC inhibitor. Intriguingly, MANT-GTPγS inhibits AC5 and -6 more potently than other cyclases. These ...

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