Rottlaender, Dennis, Matthes, Jan, Vatner, Stephen F., Seifert, Roland and Herzig, Stefan
(2007)
Functional Adenylyl Cyclase Inhibition in Murine
Cardiomyocytes by 2'(3')-O-(N-Methylanthraniloyl)-Guanosine
5'-[γ-Thio]triphosphate.
Journal of Pharmacology and Experimental Therapeutics 321 (2), pp. 608-615.
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Other URL: http://jpet.aspetjournals.org/cgi/content/abstract/321/2/608
Abstract
β₁-Adrenergic receptor activation stimulates cardiac L-type Ca²⁺ channels via adenylyl cyclases (ACs), with AC5 and AC6 being the most important cardiac isoforms. Recently, we have identified 2'(3')-O-(N-methylanthraniloyl)-guanosine 5'-[γ-thio-]triphosphate (MANT-GTPγS) as a potent competitive AC inhibitor. Intriguingly, MANT-GTPγS inhibits AC5 and -6 more potently than other cyclases. These ...
Export bibliographical data
| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 2007 | ||||
| Institutions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmacology and Toxicology (Prof. Schlossmann, formerly Prof. Seifert) | ||||
| Identification Number: |
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| Dewey Decimal Classification: | 500 Science > 570 Life sciences 600 Technology > 610 Medical sciences Medicine | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Unknown | ||||
| Item ID: | 2668 |
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