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- URN to cite this document:
- urn:nbn:de:bvb:355-epub-26684
Abstract
beta(1)-Adrenergic receptor activation stimulates cardiac L-type Ca2+ channels via adenylyl cyclases (ACs), with AC5 and AC6 being the most important cardiac isoforms. Recently, we have identified 2'(3')- O-(N-methylanthraniloyl)-guanosine 5'-[gamma-thio] triphosphate (MANT-GTP gamma S) as a potent competitive AC inhibitor. Intriguingly, MANT-GTP gamma S inhibits AC5 and -6 more potently than ...
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